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中国近30 多年的地震预报统计 1

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Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonary consolidation on computed tomography

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

《医学前沿(英文)》 2021年 第15卷 第4期   页码 585-593 doi: 10.1007/s11684-020-0817-2

摘要: Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China. Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included. Results showed that the severity-of-illness score for TEN (SCORTEN) had a good discrimination (area under the receiver operating characteristic curve (AUC), 0.78), and it was superior to auxiliary score (AS) and ABCD-10, which indicates age, bicarbonate level, cancer, dialysis, and 10% involved body surface area (AUC, 0.69 and 0.68, respectively). The calibration of SCORTEN (Hosmer–Lemeshow goodness-of-fit test, = 0.69) was also better than that of AS ( = 0.25) and ABCD-10 ( = 0.55). SCORTEN and ABCD-10 were similar (Brier score (BS), 0.04 and 0.04) in terms of accuracy of predictions. In addition, the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality. Refined models were formed using the variables and this imaging appearance. The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN (0.74 vs. 0.78, = 0.23; 0.74 vs. 0.78, = 0.30, respectively). Therefore, SCORTEN showed good discrimination performance, calibration, and accuracy, and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.

关键词: Stevens–Johnson syndrome     toxic epidermal necrolysis     auxiliary score     ABCD-10     pulmonary consolidation    

rice genotypes in stress environments: fine-tuning a selection method using production and resilience score

《农业科学与工程前沿(英文)》 doi: 10.15302/J-FASE-2023521

摘要:

● Score index methods readily discriminate genotypes adapted to a target environment.

关键词: Aerobic rice     breeding selection     drought resilience     production capacity index     resilience capacity index     stress score index     upland    

中国先进半导体材料及辅助材料发展战略研究

“先进半导体材料及辅助材料”编写组

《中国工程科学》 2020年 第22卷 第5期   页码 10-19 doi: 10.15302/J-SSCAE-2020.05.002

摘要:

目前,以SiC、GaN为代表的第三代半导体材料快速发展,我国亟需抓住战略机遇期,实现先进半导体材料、辅助材料的自主可控,保障相关工业体系安全。本文在分析全球半导体材料及辅助材料研发与产业发展现状的基础上,寻找差距,结合我国现实情况,提出了构建半导体材料及辅助材料体系化发展、上下游协同发展和可持续发展的发展思路,制定了面向2025年和2035年的发展目标。为推动我国先进半导体材料及辅助材料产业发展,提出了建设集成电路关键材料及装备自主可控工程,SiC和GaN半导体材料、辅助材料、工艺及装备验证平台,先进半导体材料在第五代移动通信技术、能源互联网及新能源汽车领域的应用示范工程,并对如何开展三项工程进行了需求分析,设置了具体的工程目标和工程任务。最后,为推动半导体产业的创新发展,从坚持政策推动,企业和机构主导,整合国内优势资源;把握“超越摩尔”的历史机遇,布局下一代集成电路技术;构建创新链,进行创新生态建设等方面提出了对策建议。

关键词: 先进半导体材料     辅助材料     第三代半导体     2035    

基于平衡记分卡的连锁经营企业绩效评价研究

曹杰,曹国,何建敏

《中国工程科学》 2008年 第10卷 第4期   页码 90-96

摘要:

以平衡记分卡(BSC)为基础,从BSC的财务、客户、内部经营过程以及学习与成长等方面,设计了连锁经营企业的绩效考核指标体系与模糊综合评判模型,克服了传统评价体系的不足,有利于从成长的角度全面评价连锁企业绩效。

关键词: 平衡记分卡     连锁经营     绩效评价     模糊综合评价    

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

《医学前沿(英文)》 2017年 第11卷 第4期   页码 563-569 doi: 10.1007/s11684-017-0535-6

摘要:

The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.

关键词: blastocyst     embryo transfer     cumulative pregnancy rate     cumulative live birth rate     IVF    

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

《医学前沿(英文)》 2019年 第13卷 第3期   页码 365-377 doi: 10.1007/s11684-018-0641-0

摘要: Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies. In this study, we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset ( =3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression, which included the following variables: male patients, induction chemotherapy for newly diagnosed or relapsed disease, neutropenia, neutropenia longer than 10 days, hypoalbuminemia, central-venous catheter, and history of IFD. The patients were classified into three groups, which had low (0–10, ~1.2%), intermediate (11–15, 6.4%), and high risk (>15, 17.5%) of IFD. In the validation set ( =1389), the IFD incidences of the groups were ~1.4%, 5.0%, and 21.4%. In addition, we demonstrated that anti-fungal prophylaxis offered no benefits in low-risk patients, whereas benefits were documented in intermediate (2.1% vs. 6.6%, =0.007) and high-risk patients (8.4% vs. 23.3%, =0.007). To make the risk score applicable for clinical settings, a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established, and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD. In conclusion, an objective, weighted risk score for IFD was developed, and it may be useful in guiding antifungal prophylaxis.

关键词: invasive fungal diseases     hematological malignancies     chemotherapy     risk score     prophylaxis    

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

《医学前沿(英文)》 2021年 第15卷 第4期   页码 621-628 doi: 10.1007/s11684-020-0738-0

摘要: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

关键词: early breast cancer     21-gene assay     recurrence score     prognosis    

一种基于辅助信息的新型位置监测累积和中值控制图 Regular Papers

Shahid HUSSAIN, Li-xin SONG, Shabbir AHMAD, Muhammad RIAZ

《信息与电子工程前沿(英文)》 2019年 第20卷 第4期   页码 554-570 doi: 10.1631/FITEE.1700428

摘要: 控制图能检测过程参数变化,是统计过程控制常用工具。休哈特控制图能有效监测大位移,而累积和(CUSUM)控制图能有效监测中、小位移。控制图在使用时通常假定数据无异常值,并且参数已知或已正确估计。实际应用中,某些过程偶尔出现异常值,所以这些假设通常不成立。位置参数监测通常基于均值控制图,严重受不成立假设影响。本文提出几种基于辅助变量的累积和中值控制图,并与其相对应均值控制图进行比较。为监测位置参数,分别检测包含与不含异常值时均值和中值控制图性能。研究对称与非对称过程,并利用累积和控制图监测位置参数,进一步研究所提控制图性能。基于不同运行链长,研究受控和非受控累积和控制图性能。结果表明,存在异常值时,所提控制图比传统控制图性能更优。最后,提供了一个基于混凝土抗压强度与生产质量关系的应用实例。

关键词: 平均运行链长;辅助信息;累积和控制图;位置参数;中值控制图    

基于人工智能技术的儿童ADHD辅助诊断系统 Research

张雁翼1,孔鸣2,赵天琦2,洪文琛2,谢迪3,王春茂3,杨荣旺1,李荣1,朱强2

《信息与电子工程前沿(英文)》 2021年 第22卷 第3期   页码 400-414 doi: 10.1631/FITEE.1900729

摘要: 传统的儿童注意缺陷多动障碍(ADHD)诊断主要基于由父母/老师填写的调查问卷和医生的临床观察,不仅效率不高,而且诊断准确率很大程度上取决于医生的经验水平。本文将人工智能技术结合到一种软硬件协同辅助诊断系统中,以使ADHD诊断更为高效。通过集成智能分析模块,相机模组将采集受试儿童完成执行功能测试时的眼部注意力、面部表情、3D身体姿态和其他测试信息。然后,提出一种多模态深度学习模型,用于对所采集视频中儿童的异常行为片段进行分类。结合其他系统模块所采集的信息,辅助诊断系统能够自动生成标准化的诊断报告,包括测试结果、异常行为分析、辅助诊断结论和治疗建议。该系统目前实际部署在浙江大学医学院附属儿童医院心理科,用于临床辅助诊断,得到医生和患者一致好评。

关键词: 注意缺陷多动障碍(ADHD);辅助诊断;计算机视觉;深度学习;BERT    

Availability growth models and verification of power equipment

Jinyuan SHI, Jiamin XU

《能源前沿(英文)》 2021年 第15卷 第2期   页码 529-538 doi: 10.1007/s11708-019-0624-0

摘要: The general availability growth models for large scale complicated repairable system such as electric generating units, power station auxiliaries, and transmission and distribution installations are presented. The calculation formulas for the maintenance coefficient, mathematical expressions for general availability growth models, ways for estimating, and fitting on checking the parameters of the model are introduced. Availability growth models for electric generating units, power station auxiliaries, and transmission and distribution installations are given together with verification examples for availability growth models of 320–1000 MW nuclear power units and 1000 MW thermal power units, 200–1000 MW power station auxiliaries, and 220–500 kV transmission and distribution installations. The verification results for operation availability data show that the maintenance coefficients for electric generating units, power station auxiliaries, transmission and distribution installations conform to the power function, and general availability growth models conform to rules of availability growth tendency of power equipment.

关键词: repairable system     power equipment     electric generating unit     power station auxiliary     transmission and distribution installation     reliability     availability     availability growth model    

skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation: PAH risk score

《医学前沿(英文)》 2022年 第16卷 第6期   页码 957-968 doi: 10.1007/s11684-021-0910-1

摘要: Skin and soft tissue infections (SSTIs) refer to infections involving the skin, subcutaneous tissue, fascia, and muscle. In transplant populations with hematological malignancies, an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly. However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation (HSCT) patients remain unclear. This study included 228 patients (3.67%) who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People’s Hospital. The overall annual survival rate was 71.5%. We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure (PPGF), comorbidities of acute kidney injury (AKI), and hospital-acquired pneumonia (HAP) were independent risk factors for death in the study population. A PPGF–AKI–HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI+1×HAP. The areas under the curves of internal and external validation were 0.833 (95% CI 0.760–0.906) and 0.826 (95% CI 0.715–0.937), respectively. The calibration plot revealed the high consistency of the estimated risks, and decision curve analysis showed considerable net benefits for patients.

关键词: skin and soft tissue infections     hematopoietic stem cell transplantation     risk stratification system     mortality    

Three-dimensional electromagnetic analysis and design of permanent magnet retarder

Lezhi YE, Desheng LI, Bingfeng JIAO

《机械工程前沿(英文)》 2010年 第5卷 第4期   页码 438-441 doi: 10.1007/s11465-010-0111-0

摘要: An eddy current retarder for vehicles generates much heat when it works continuously, which leads to serious decline in braking torque. This paper proposes a novel permanent magnet retarder (PMR) for vehicles, whose cooling system connects with engine cooling-water. A three-dimensional finite element model is developed to model the electromagnetic behavior of a permanent magnet retarder under a constant speed. The magnetic field and eddy current field in PMR are numerically solved by a finite element method. By accounting for the nonlinear permeability of the rotor and the weakened effect in the magnetic field that is generated by the eddy current magnetic field, the calculation accuracy of air-gap magnetic field is enhanced. Experiment shows that the temperature of the retarder is less than 150°C, and the braking torque keeps the hard characteristics curve. The calculated air-gap magnetic flux density is fairly good agreement with the measured one.

关键词: auxiliary brake     permanent magnet retarder     water-cooling     finite element method    

我国地震预测成绩的回顾与统计

高建国

《中国工程科学》 2009年 第11卷 第6期   页码 129-131

摘要:

地震预测预报的难度大,但并非了无痕迹或不可知,我国每次较大的地震都有案例总结。统计表明,近40 年来,有77 次地震在发生前均有中期、短期甚至临震预测,不能因为汶川地震预测的失败,就全面抹杀中国的地震预报成绩,即我国的地震预测成绩是应予肯定的,汶川地震也并非是无前兆的“怪震”。

关键词: 地震     地震预测     中国近30 多年的地震预报统计    

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

《医学前沿(英文)》 2019年 第13卷 第1期   页码 32-44 doi: 10.1007/s11684-018-0678-0

摘要:

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.

关键词: immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

国际固体氧化物燃料电池堆及系统

苏巴 辛格尔

《中国工程科学》 2013年 第15卷 第2期   页码 7-14

摘要:

为了实现固体氧化物燃料电池(SOFC)的广泛应用,世界上许多公司正在致力于SOFC的开发、制造和商业化研究。本文回顾和讨论了SOFC领域的相关发展现状。

关键词: SOFC     SOFC电池堆     管式电池     热电联供     辅助动力单元    

标题 作者 时间 类型 操作

Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonary consolidation on computed tomography

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

期刊论文

rice genotypes in stress environments: fine-tuning a selection method using production and resilience score

期刊论文

中国先进半导体材料及辅助材料发展战略研究

“先进半导体材料及辅助材料”编写组

期刊论文

基于平衡记分卡的连锁经营企业绩效评价研究

曹杰,曹国,何建敏

期刊论文

Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo

null

期刊论文

Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing

Ling Wang, Ying Wang, Jiong Hu, Yuqian Sun, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang

期刊论文

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

期刊论文

一种基于辅助信息的新型位置监测累积和中值控制图

Shahid HUSSAIN, Li-xin SONG, Shabbir AHMAD, Muhammad RIAZ

期刊论文

基于人工智能技术的儿童ADHD辅助诊断系统

张雁翼1,孔鸣2,赵天琦2,洪文琛2,谢迪3,王春茂3,杨荣旺1,李荣1,朱强2

期刊论文

Availability growth models and verification of power equipment

Jinyuan SHI, Jiamin XU

期刊论文

skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation: PAH risk score

期刊论文

Three-dimensional electromagnetic analysis and design of permanent magnet retarder

Lezhi YE, Desheng LI, Bingfeng JIAO

期刊论文

我国地震预测成绩的回顾与统计

高建国

期刊论文

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

期刊论文

国际固体氧化物燃料电池堆及系统

苏巴 辛格尔

期刊论文